Cardiovascular Vitamin D is a fat-soluble vitamin

Cardiovascular
disease (CVD) is a class of diseases involving  heart or blood
vessels. 1 Cardiovascular
diseases account for more deaths worldwide than any other disease. It resulted in 17.9 million
deaths (32.1%) in 2015, up from 12.3 million (25.8%) in 1990.2

Obesity is a major risk
factors for a number of chronic diseases, including cardiovascular diseases.
other risk factors includes hypertension, dyslipidaemia and impaired glucose
tolerance/insulin resistance.3

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Vitamin D is a
fat-soluble vitamin that functions as a steroid hormone and  It has been recognized as a vitamin which is
essential for bone–mineral health. In the past two decades, numerous
experimental and observational studies have highlighted the role of vitamin D
in immunity, metabolic syndrome (obesity and diabetes), cancers, renal disease,
memory, and neurological dysfunction.4 Furthermore, studies have suggested a potential role of
25-hydroxyvitamin D (25-OH-D), the major circulating form of vitamin D, in decreasing
 risk of cardiovascular diseases (CVD)
5

Although the underlying biological causes are not fully
understood, the link  between Vitamin D
and cardiovascular pathology is speculated to be driven by various mechanisms. It
may be due to potential direct impact on cardiomyocytes and myocardial
diseases. it has been suggested that 25-OH-D indirectly modifies CVD risk by
its association with cardiovascular risk factors like obesity, diabetes,
hypertension, smoking, or cholesterol level. However, vitamin D physiology and dosage may differ
according to body weight.  individuals
with obesity require higher doses of vitamin D in order to improve their
vitamin D status compared to subjects with normal weight 6Hypovitaminosis D
is linked with the cardiovascular disease 7

A meta-analysis is the
need of the hour in evaluating role of vitamin D and cardiovascular diseases.
particularly in obese individuals.

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