A double-blind, randomized, and placebo-controlled trial studied

A double-blind,
randomized, and placebo-controlled trial studied whether St. John’s Wort
extract were effective for the treatment of depression with atypical features. This
studied included subjects between 18 and 70 years of age who were suffering
from atypical depression. The International Classification of Diseases Tenth
Revision, Clinical Modification criteria for mild or moderate depression had to
be met along with duration of symptoms lasting for 3 months. Subject needed to
meet a score of two points in at least one of the items 22-26 of the Hamilton-Depression-Rating-Scale.

Screening excluded subjects exhibiting vegetative features of melancholic
depression; in addition, with episode of melancholic depression, organic mental
disorders, personality disorders, substance abuse, alcohol, seasonal
depression, current serious suicidality risk and postpartum depression. Extra
exclusion criteria were non-adrenergic agonist, the use of corticosteroids,
magnesium supplements and gyrase inhibitors. Randomization occurred with a help
of a computer software. 

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